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KMID : 1123920030170061528
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Korean Journal of Oriental Physiology and Pathology
2003 Volume.17 No. 6 p.1528 ~ p.1532
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Comparison of Relative Antioxidant Capacity and Antiperoxidation Activity of Traditional Medicines in Vitro
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Yeom Gee-Bok
Kim Won-Sin
Lee Chai-Ho
Jang Ho-Yeon
Kang Jeong-Ho
Park Shin-Ki
Lee Key-Sang
Jeon Byung-Hoon
Lee Hyung-Cheol
Ju Sung-Min
Kim Kun-Jung
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Abstract
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To investigate the antioxidant capacity of traditional Korean medicines, water extracts from 57 species were tested on their antioxidant activity using radical scavenging effects against ABTSㆍ+. Of which, Rhus javanica, Caesalpinia sappan, Rosa rugosa, Spatholobus suberectus, and Magnolia obovata showed strong antioxidant capacities at 10㎍ concentration. Therefore, antioxidant capacities of 5 traditional medicine extracts in the different concentration (1㎍, 5㎍, and 10㎍) were determined. The 5 traditional medicine extracts was detected in antioxidant capacity dose dependently. R. javanica was showed the highest antioxidant capacity, the antioxidant activity at 1 ㎍ of herbal extract being 0.85 mM TE. At the same time, the antiperoxidation effects of these 5 medicines were determined. Lipid peroxidation in brain homogenates induced by NADPH and ADP-Fe/sup 2+/ was strong inhibited by S, suberectus, R. rugosa, and M. obovata. Extract of C. sappan was showed the highest inhibition against lipid peroxidation compared with 4 herbal extracts in vitro. These traditional medicines are a potent antioxidant capacity and antiperoxidation activity, further investigation into the in vivo antioxidant therapeutic potential for treatment of human disorders such as Alzheimer’s disease.
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KEYWORD
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Caesalpinia sappan, Antioxidant capacity, Antiperoxidation activity, Traditional medicine
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